Silver Nanoparticles Induced Cardiac Toxicity
Published: 2021-01-11
Page: 54-60
Issue: 2020 - Volume 3 [Issue 1]
Yasmeen M. Amer
Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
Afaf Elatrash
Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
Ehab Tousson *
Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Aim: Silver nanoparticles (Ag NPs) have been utilized in a wide assortment of uses as antimicrobial specialists and have been fused into a few items as mechanical and food items not withstanding natural and clinical applications. Inordinate utilization of nanoparticles might be dangerous to human wellbeing and the climate. No sufficient information present about the toxic effect of silver nanoparticles on heart. Accordingly, The current study aimed to investigate the cardiac toxicity of silver nanoparticles.
Study Design: A total 20 male Wistar rats were divided into 2 equivalent groups (Group 1, control; group 2, Ag NPs).
Results: Current results revealed that; Ag NPs induced a significant decrease in serum e kinase myoglobin (CK-MB), phosphokinase (CPK), myoglobin, alkaline phosphatase (ALP) and aspartate aminotransferase (AST), cholesterol, triglycerides, and low-density lipids (LDL) while they cause a significant depletion in the levels of high-density lipids (HDL) in the sera of Ag NPs group (Gp2) when compared with the control group (Gp1).
Conclusion: The present study confirmed that; silver nanoparticles (Ag NPs) induced cardiac toxicity in rats.
Keywords: Silver nanoparticles, heart, cardiac enzymes, lipid profiles, rats